Download PDF by Dieter Huhn,Klaus P. Hellriegel,Norbert Niederle: Chronic Myelocytic Leukemia and Interferon:

By Dieter Huhn,Klaus P. Hellriegel,Norbert Niederle

experiences at the impact of recombinant human interferon (rIFN) at the development of colonies of multi strength hematopoietic progenitors have verified that IFN inhibits the expansion of those cells in tradition. The inhibitory impression of IFN was once extra suggested in multilineage colony forming cells (CFU-GEMMT) of marrow cells of sufferers with persistent myelogenous leukemia (CML) in comparison with stern cells of ordinary marrow. T phone colony formation (CFU-TL) of phi_positive T cells received from basic multilineage hematopoietic colonies was once inhibited by way of rIFN. Inhibition of T cellphone colony formation of Phi T cells was once extra profound via IFN in comparison with secondary T cells of fit participants. Southern blot research of secondary T cells from basic members published a germ line trend whilst tested for T mobilephone receptor (TcR) gene re preparations utilizing the cDNA of the beta chain. Subcloned Phi T cells of 1 sufferer with CML verified gene rearrangements of the TcR. We additionally validated the disappearance of phi_positive multilineage hematopoietic colonies whilst marrow cells have been preincubated with IFN and in this case cultured within the presence of IFN. The cytoconversion of the Phi chromosome in metaphases got from separately analyzed multilineage hematopoietic colonies means that IFN may let the recovery of nonclonal hematopoiesis in sufferers with CML. Acknowledgement. Supported partly through Deutsche Forschungsgemeinschaft and the scientific study Council of Canada. References 1. Koeffler HP, Golde DW (1981) power myelogenous 1eukelnia - new concepts.

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Chronic Myelocytic Leukemia and Interferon: Pathophysiological, Clinical and Therapeutical Aspects by Dieter Huhn,Klaus P. Hellriegel,Norbert Niederle


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